Liposomes Vs Regular (Water-Soluble) Supplements

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Liposomes Vs Traditional Supplements

(Almost everything you need to know about the Liposomal technology, and the benefits)

If there is one major issue that plagues supplements (and medicines), it is bioavailability. In other words, “how easily something is absorbed by our bodies”. 

It may be heart-wrenching to learn that most of the vitamins that we consume are destroyed before they reach our cells, or leave us in the form of (very expensive) wee. 

Vitamin C is a great example of this. Most supplements we buy contain up to 1000mgs of Vitamin C (usually in the form of ascorbic acid), however, it seems that studies have shown that 75%-90% of the vitamin at doses between 30-150mgs  Anything above 1000mg (1g) only 50% is absorbed. 

The same goes for many other vitamins, minerals and compounds that are far less bioavailable than Vitamin C. 

CBD (Cannabinoids) via oral consumption are between 5-6% bioavailable [source] which is extremely low. 

There is a solution though- Liposomomes. This post is dedicated to what they are, what their benefits are & how we can use them to increase the bioavailability (and therefore, active doses) of vitamins, minerals and CBD. 



Click this link if you’re only really interested in Liposomal CBD (it will scroll you down to the relevant bits)


What Are Liposomes?

Liposomes are microscopic bubbles which are designed to encapsulates a valuable substance (like vitamins, minerals or medications). 

They are formed with one, or many, lipid bilayers (layers of fat) which are remarkably similar to the building blocks of our cell membranes. The fatty layer surrounds aqueous (watery) solutions inside which can contain water-soluble (vitamin C) or fat-soluble compounds (like CBD). 




They have been designed to ensure that the valuable substance inside of the fatty bubble is ‘shielded from the harsh environment in our gut’, but also can be seamlessly absorbed by our cells, resulting in a dramatic increase in bioavailability. 



Why are they so great? 

As you can see in the image above, the Liposome’s outer layer is created from Phospholipids, which are what makes up the membrane of our cells. 

Traditionally, Vitamin C is a naturally water-soluble substance. When we eat food which is naturally rich in Vitamin C (like an orange) or drink a water-based supplement the Vitamin enters our gut and moves past our millions of cells which make up the lining of our intestines. 

The water-soluble vitamin is absorbed into our cells via a protein transporter called SCV2 that lives in our gut lining.

Imagine the transporter like a little gate – it catches a molecule as it passes by and pulls it in. The transporter is very slow and can only consume a small amount at once. This is the reason why bioavailability of vitamin C drops to 50% at 1000mgs. 

Liposomes are designed to bypass this transportation protein and be absorbed directly into the cell. As an added benefit, the gut is usually quite a dangerous environment for unprotected vitamins, and they degrade quite quickly in our stomach acid. The liposomal layer acts like a shield and protects the vitamins too. 

What exactly does that mean:

  • Between 2X & 4X more bioavailable: Not only do Liposomes increase the amount of bioactives in your blood stream, but they stay there for significantly longer. 
  • 10X more Bioprotection: Liposomal substances are destroyed 10X less than non-liposomal vitamins. 
  • Biocompatibility: Made from natural lipids, reducing the risk of toxicity.
  • Controlled Release: Allow for sustained release of the encapsulated substance.


The data

There are lots and lots of studies looking at this, and we’ve found a huge variance between the results. It is clear, that Liposomes are significantly more bioavailable than traditional methods. 

During a study [source] it was found that Liposomal vitamin C increased vitamin C levels in blood plasma by over 2X compared to water-soluble Vitamin C. 
Over a period of 4 hours, you can see that encapsulated compounds were found in the blood a higher levels, and for dramatically longer. 




Liposomal CBD

As mentioned at the beginning of the article, CBD is one such compound that is specifically hard for our body to absorb. The compounds are quite delicate struggles to find their way into our Cells.

Unless the CBD is absorbed via the sublingual gland, the CBD is processed via our digestive system and liver. Only a small amount of CBD is absorbed by the body and the rest bounces around, becoming damaged and wasted.

Thankfully, Cannabinoids happily bind to fat, which means that eating a fatty meal before consuming CBD increases its bioavailability. Even better, CBD wraps itself inside the phospholipids perfectly. 

Just like vitamin C, the absorption rate of CBD is dramatically increased by being encapsulated within a Liposome. A study showed that the increase was as much as 253.1% [source] increasing CBD’s bioavailability from aprox 6% to aprox 15%.


The real benefit of Liposomal CBD is that the cannabinoid compounds are protected while they enter our tummies. Some research suggests that the presence of ‘lecithin’ (found in most Liposomal formuals) helps to ‘smooth’ out the fatty cannabinoid compounds, making them easier to process. 

The result? There will be a high concentration of CBD in your body for longer, and less waste. 

While the jury is still out on exactly how effective these are, there is no doubt that a Liposomal CBD supplement goes further. When you try a supplement like this, you will see that it comes on quicker, and stronger. 

Almost everybody who tries a Liposomal CBD formula notices the difference.